Castagnola E, Lanino E, Garaventa A, Dini G, Dallorso S, Carrega G, Viscoli C
Department of Infectious Diseases, G. Gaslini Children's Hospital, Genoa, Italy.
Support Care Cancer. 1995 Sep;3(5):319-21. doi: 10.1007/BF00335310.
The work described aimed to evaluate the incidence of streptococcal bacteraemia in children undergoing bone marrow transplantation and receiving prophylaxis with penicillin V. From January 1991 to December 1993 oral penicillin V was administered as prophylaxis for streptococcal bacteraemia to patients undergoing bone marrow transplantation at G. Gaslini Children's Hospital, Genoa, Italy. The data were compared with those from a similar population receiving bone marrow transplantation from September 1984 to July 1990 and not receiving this kind of prophylaxis. Streptococcal bacteraemia was diagnosed in 7/17 (41%) episodes of bacteraemia observed in the period January 1991 to December 1993, while it accounted for 71% of all bacteraemias in the period from September 1984 to July 1990 and was especially frequent from January 1988 to July 1990, comprising 13/15 (87%) of observed bacteremias. The decrease of this complication observed after the beginning of the prophylaxis programme was statistically significant. Oral penicillin V is effective as prophylaxis of streptococcal bacteraemias in children receiving bone marrow transplantation in a centre with a high incidence of this complication.
所述工作旨在评估接受骨髓移植并接受青霉素V预防治疗的儿童中链球菌菌血症的发生率。1991年1月至1993年12月，意大利热那亚G. Gaslini儿童医院对接受骨髓移植的患者口服青霉素V以预防链球菌菌血症。将这些数据与1984年9月至1990年7月接受骨髓移植且未接受此类预防治疗的类似人群的数据进行比较。在1991年1月至1993年12月期间观察到的17次菌血症发作中有7次（41%）诊断为链球菌菌血症，而在1984年9月至1990年7月期间，链球菌菌血症占所有菌血症的71%，在1988年1月至1990年7月期间尤为常见，占观察到的菌血症的13/15（87%）。预防方案开始后观察到的这种并发症的减少具有统计学意义。在该并发症发生率较高的中心，口服青霉素V对接受骨髓移植的儿童预防链球菌菌血症有效。
