Hlavácová H, Csöllei J, Seginko J
Katedra farmaceutické chemie Farmaceutické fakulty Univerzity Komenského, Bratislava.
Ceska Slov Farm. 1995 Oct;44(5):261-4.
The synthesis of nine compounds belonging to the group of aryloxyaminopropanols with carbamate substitutions of the aromatic ring is described and pharmacologically evaluated. The results suggest that an addition of N-phenyl-piperazine derivatives to the main basic moiety can exert a positive influence on their beta-adrenolytic, antiarrhytmic or antihypertensive activity.
描述了属于芳氧基氨基丙醇类且芳香环带有氨基甲酸酯取代基的九种化合物的合成,并进行了药理学评估。结果表明,在主要碱性部分添加N-苯基哌嗪衍生物可对其β-肾上腺素能阻断、抗心律失常或抗高血压活性产生积极影响。