Chen J S, Liaw C C, Wang H M, Tsai M H, Hao S P, Hsueh S
Department of Internal Medicine and, Otolaryngology, Chang Gung Memorial Hospital, Taipei, Taiwan, R.O.C.
Changgeng Yi Xue Za Zhi. 1995 Sep;18(3):260-5.
Seven cases with Osteosarcoma (OS) of the jaw were retrospectively reviewed. There were five female and two male patients. Their ages ranged from 14 to 57 years with a mean of 39 years. Seventy-one percent of the patients were older than 30 years old. Jaw swellings were the most frequent complaints occurring on an average of 3 months before diagnosis. Four cases occurred in mandible and three cases developed from maxilla. Most cases were lytic lesions on roentgenography. Four were osteoblastic, 2 were chondroblastic, and 1 was histologic classification. Six of the 7 cases received surgery. Postoperatively, 3 of them received both radiotherapy and chemotherapy, 1 received chemotherapy only and 1 received radiotherapy only. One case received palliative chemotherapy only because of the locally far advanced disease. Four cases died of regional failure without any metastatic lesions (survival ranged from 5 months to 22 months). Two cases survived more than 4 years without any recurrence. The median survival time was 22 months. We concluded that OS of the jaw has different natural courses from OS of the long bones and the regional failure seems to be the main problem in jaw OS.
对7例颌骨骨肉瘤（OS）患者进行回顾性研究。其中女性5例，男性2例。年龄范围为14至57岁，平均年龄39岁。71%的患者年龄超过30岁。颌骨肿胀是最常见的症状，平均出现在诊断前3个月。4例发生在下颌骨，3例发生在上颌骨。大多数病例在X线片上表现为溶骨性病变。4例为成骨型，2例为软骨型，1例为组织学分类。7例患者中有6例接受了手术。术后，其中3例接受了放疗和化疗，1例仅接受化疗，1例仅接受放疗。1例因局部病情进展严重仅接受了姑息性化疗。4例死于局部复发，无任何转移病灶（生存时间为5个月至22个月）。2例存活超过4年且无任何复发。中位生存时间为22个月。我们得出结论，颌骨骨肉瘤与长骨骨肉瘤有不同的自然病程，局部复发似乎是颌骨骨肉瘤的主要问题。
