儿童和青年颌骨骨肉瘤。
Osteosarcoma of the jaw in children and young adults.
机构信息
Division of Pediatrics, Children's Cancer Hospital of The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
出版信息
Head Neck. 2012 Jul;34(7):981-4. doi: 10.1002/hed.21850. Epub 2011 Aug 18.
BACKGROUND
Pediatric jaw osteosarcoma is uncommon, and data are scarce regarding clinical presentation, prognostic factors, and outcome.
METHODS
A single-institution medical record review from 1983 to 2008 for 12 patients age ≤ 21 years was undertaken for this study.
RESULTS
Median diagnosis age was 16.3 years (range, 6.3-21.9). Nine patients had mandible tumors. Osteoblastic subtype was most common (4 patients). Most tumors were large (ie, T2; n = 8) and high-grade (n = 8). Treatment characteristics were varied. Median follow-up was 27.1 months (range, 8-252 months). Five patients had tumor necrosis <80% after chemotherapy. No deaths were observed.
CONCLUSION
Jaw osteosarcoma outcome is better compared to extremity osteosarcoma, but further study is required regarding clinical prognostic factors.
背景
小儿颌骨骨肉瘤较为罕见，有关其临床表现、预后因素和转归的数据有限。
方法
本研究对 1983 年至 2008 年期间 12 名年龄≤21 岁的患者进行了单机构病历回顾。
结果
中位诊断年龄为 16.3 岁（范围为 6.3-21.9 岁）。9 名患者患有下颌骨肿瘤。成骨亚型最为常见（4 例）。大多数肿瘤较大（即 T2；n=8）且为高级别（n=8）。治疗特征各异。中位随访时间为 27.1 个月（范围为 8-252 个月）。5 名患者化疗后肿瘤坏死率<80%。无死亡病例。
结论
与肢体骨肉瘤相比，颌骨骨肉瘤的预后更好，但需要进一步研究有关临床预后因素。
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