Odano I, Takahashi N, Higuchi T, Ohkubo M, Hama S, Tsuda A, Otaki H, Noguchi E, Hatano M
Department of Radiology, Niigata University School of Medicine, Japan.
Clin Nucl Med. 1995 Sep;20(9):807-9. doi: 10.1097/00003072-199509000-00010.
To determine whether regional cerebral blood flow (rCBF) would change on standing in patients with idiopathic orthostatic hypotension (IOH), Tc-99m HMPAO SPECT studies were performed during postural testing in five patients with IOH. After 10 minutes of quiet rest on a bed, the patients arose quickly and, at the same time, the radiotracer was injected intravenously. SPECT data were obtained with a ring-type SPECT scanner. Another dose of Tc-99m HMPAO was injected with the subjects in the supine position, and SPECT was performed again. Image subtraction was used to evaluate the change in rCBF caused by postural testing. In all patients, the authors observed a decrease of rCBF ni the frontal cortex and basal ganglia. This preliminary study suggests that changes in rCBF occur in patients with IOH on standing, and Tc-99m HMPAO SPECT performed during postural testing may have an important role in evaluating these changes.
为了确定特发性直立性低血压（IOH）患者站立时局部脑血流量（rCBF）是否会发生变化，对5例IOH患者在体位测试期间进行了锝-99m六甲基丙二胺肟单光子发射计算机断层扫描（Tc-99m HMPAO SPECT）研究。患者在床上安静休息10分钟后迅速起身，与此同时静脉注射放射性示踪剂。使用环形SPECT扫描仪获取SPECT数据。让受试者在仰卧位时再注射一剂Tc-99m HMPAO，然后再次进行SPECT检查。采用图像减法来评估体位测试引起的rCBF变化。在所有患者中，作者观察到额叶皮质和基底神经节的rCBF下降。这项初步研究表明，IOH患者站立时rCBF会发生变化，体位测试期间进行的Tc-99m HMPAO SPECT可能在评估这些变化中发挥重要作用。
