Broome M, Clayton J, Fotherby K
Family Planning Clinic, Reading, England.
Contraception. 1995 Jul;52(1):13-6. doi: 10.1016/0010-7824(95)00127-v.
Ultrasound examination of the ovaries was performed in the first and/or second half of three consecutive cycles in 3 groups of women; Group T who had been using a levonorgestrel triphasic oral contraceptive for at least 6 months, Group P who had been using a progestogen-only pill for at least 6 months, and Group C, a control group. Any follicles greater than 10 mm in diameter and any cysts were measured. Fifty-three scans were performed in Group T, 45 in Group P and 31 in Group C. Only 4 follicles were detected in 17 women in Group T compared to 10 follicles in 15 women in Group P and 7 follicles in the women in Group C; all follicles were 25 mm or less in diameter except for 3 follicles in 2 women. The differences between the groups were not statistically significant. Four enlarged follicles were detected in 3 women during 53 scans in Group T, 15 in 8 women (45 scans) in Group P, and only 1 in 31 scans in Group C. Based upon the proportions of scans with enlarged follicles, the difference between Groups T and P was statistically significant, indicating that the incidence of enlarged follicles was lower in women using a combined oral contraceptive than in those using a progestogen-only pill. Furthermore, the study shows that any enlarged follicles which occurred were transient.
对三组女性在连续三个周期的上半周期和/或下半周期进行卵巢超声检查；T组女性至少使用左炔诺孕酮三相口服避孕药6个月，P组女性至少使用仅含孕激素的避孕药6个月，C组为对照组。测量任何直径大于10毫米的卵泡和任何囊肿。T组进行了53次扫描，P组进行了45次扫描，C组进行了31次扫描。T组17名女性中仅检测到4个卵泡，相比之下，P组15名女性中有10个卵泡，C组女性中有7个卵泡；除2名女性中的3个卵泡外，所有卵泡直径均为25毫米或更小。各组之间的差异无统计学意义。T组在53次扫描中有3名女性检测到4个增大的卵泡，P组在8名女性（45次扫描）中有15个，C组在31次扫描中仅有1个。根据有增大卵泡的扫描比例，T组和P组之间的差异具有统计学意义，表明使用复方口服避孕药的女性中增大卵泡的发生率低于使用仅含孕激素避孕药的女性。此外，研究表明出现的任何增大卵泡都是短暂的。
