亚胺培南与其他五种抗铜绿假单胞菌药物对庆大霉素敏感和耐药铜绿假单胞菌的比较。
Comparison of imipenem and five other antipseudomonal agents against gentamicin-susceptible and -resistant Pseudomonas aeruginosa.
作者信息
Gerçeker A A, Otük G
机构信息
Department of Pharmaceutical Microbiology, Faculty of Pharmacy, University of Istanbul, Turkey.
出版信息
Chemotherapy. 1995 Sep-Oct;41(5):334-6. doi: 10.1159/000239364.
The in vitro activities of imipenem, aztreonam, piperacillin, ciprofloxacin and amikacin were tested by the microbroth dilution technique against 86 clinical isolates of Pseudomonas aeruginosa. Imipenem and ciprofloxacin were the most active agents against gentamicin-susceptible P. aeruginosa. Only imipenem inhibited gentamicin-resistant P. aeruginosa at < or = 8 micrograms/ml. The finding that none of the gentamicin-resistant strains were resistant to imipenem and amikacin indicated the superiority of these antibiotics to the other agents in hospital-associated gentamicin-resistant P. aeruginosa infections.
采用微量肉汤稀释技术，对86株铜绿假单胞菌临床分离株检测了亚胺培南、氨曲南、哌拉西林、环丙沙星和阿米卡星的体外活性。亚胺培南和环丙沙星是对庆大霉素敏感的铜绿假单胞菌最具活性的药物。只有亚胺培南能在≤8微克/毫升时抑制耐庆大霉素的铜绿假单胞菌。耐庆大霉素菌株对亚胺培南和阿米卡星均无耐药性，这一发现表明在医院获得性耐庆大霉素铜绿假单胞菌感染中，这些抗生素比其他药物更具优势。
Zotero 插件