Pruekprasert Pornpimol, Tunyapanit Wanutsanun
Department of Pediatrics, Faculty of Medicine, Prince of Songkla University, Thailand.
Southeast Asian J Trop Med Public Health. 2005 Sep;36(5):1239-42.
The effects of antimicrobial combinations against ceftazidime-resistant Pseudomonas aeruginosa strains isolated from hospitalized patients were investigated. Using the checkerboard titration method, combination of fosfomycin-gentamicin, fosfomycin-ceftazidime, fosfomycin-imipenem and ceftazidime-gentamicin was synergistic against 4, 11, 38 and 39% of 22, 18, 29 and 18 strains tested respectively and additive effect of the combinations against the strains tested was 41, 33, 14 and 44%, respectively. Antagonistic effects against the isolates were noted when fosfomycin was combined with gentamicin (27%), ceftazidime (22%) and imipenem (7%). No antagonistic effect was observed in the ceftazidime-gentamicin combination.
研究了抗菌药物联合使用对从住院患者中分离出的耐头孢他啶铜绿假单胞菌菌株的影响。采用棋盘滴定法，磷霉素-庆大霉素、磷霉素-头孢他啶、磷霉素-亚胺培南和头孢他啶-庆大霉素联合使用分别对22株、18株、29株和18株测试菌株中的4%、11%、38%和39%具有协同作用，这些联合用药对测试菌株的相加作用分别为41%、33%、14%和44%。当磷霉素与庆大霉素（27%）、头孢他啶（22%）和亚胺培南（7%）联合使用时，对分离菌株有拮抗作用。头孢他啶-庆大霉素联合使用未观察到拮抗作用。
