Hamelin S M, Lehmann J C
Department of Neurosurgery, Medical College of Pennsylvania and Hahnemann University, Philadelphia 19102-1192, USA.
Eur J Pharmacol. 1995 Aug 15;281(3):R11-3. doi: 10.1016/0014-2999(95)00432-k.
Piracetam, aniracetam, and D-cycloserine were tested for their ability to reduce inhibition of [3H]MK801 (dizocilpine) binding by 100 microM kynurenate. Piracetam (100 microM-1 mM) failed to reduce inhibition by kynurenate but stimulated [3H]MK801 binding in the absence of kynurenate. In contrast, D-cycloserine (30 microM-1 mM) and aniracetam markedly reduced this inhibition by kynurenate. Thus, cognition enhancers might function via at least some subtypes of NMDA receptors.
对吡拉西坦、阿尼西坦和 D -环丝氨酸进行了测试，以考察它们降低 100 微摩尔犬尿氨酸对[3H]MK801（地卓西平）结合抑制作用的能力。吡拉西坦（100 微摩尔 - 1 毫摩尔）未能降低犬尿氨酸的抑制作用，但在不存在犬尿氨酸的情况下刺激了[3H]MK801 的结合。相比之下，D -环丝氨酸（30 微摩尔 - 1 毫摩尔）和阿尼西坦显著降低了犬尿氨酸的这种抑制作用。因此，认知增强剂可能至少通过某些亚型的 N -甲基 - D -天冬氨酸受体发挥作用。
