Port R L, Seybold K S
Department of Psychology, Slippery Rock University, PA 16057, USA.
Physiol Behav. 1998 Jun 1;64(3):391-3. doi: 10.1016/s0031-9384(98)00095-x.
The effects of pharmacologically manipulating N-methyl-D-aspartate(NMDA)-receptor activity were examined during extinction of an appetitive instrumental response in rats. After reaching acquisition criterion, subjects were treated with the antagonist dizocilpine maleate (MK801; 0.1 mg/kg), the agonist D-cycloserine (3 mg/kg), or vehicle-alone (control) and tested during a non-reinforced (extinction) session. The antagonist decreased the average number of responses occurring during the test session whereas the agonist increased the average number in contrast to controls. The effect on retention performance may be mediated by differential influence on the N-methyl-D-aspartate-dependent synaptic plasticity that occurs during associative learning. In conjunction with other studies, these data suggest that N-methyl-D-aspartate agonism may be an effective intervention for memory dysfunction.
在大鼠的一种条件性奖赏操作反应消退过程中，研究了对N-甲基-D-天冬氨酸（NMDA）受体活性进行药理学调控的效果。在达到习得标准后，对实验对象分别给予拮抗剂马来酸氯氮平（MK801；0.1毫克/千克）、激动剂D-环丝氨酸（3毫克/千克）或单独给予溶媒（对照组），并在无强化（消退）阶段进行测试。与对照组相比，拮抗剂减少了测试阶段出现的平均反应次数，而激动剂则增加了平均反应次数。对记忆保持表现的影响可能是通过对联想学习过程中发生的依赖N-甲基-D-天冬氨酸的突触可塑性产生不同影响来介导的。结合其他研究，这些数据表明N-甲基-D-天冬氨酸激动作用可能是对记忆功能障碍的一种有效干预措施。
