[The effect of adenosine on the hypothalamo-hypophyseal-adrenal system].

The effect of various doses of intraperitoneally administered adenosine on the content of corticotropin and corticosteroids on the blood plasma was studied in Wistar rats. Dependence of the effect exerted by adenosine on the hypothalamo-pituitary-adrenal system on its dose was demonstrated: 1 hour after nucleoside administration in a dose of 50 mg/kg corticotropin concentration increased; 1 hour after adenosine administration in a dose of 25 mg/kg the level of corticosteroids in the blood plasma decreased.