Thomas de Montpréville V, Dulmet E M
Department of Pathology, Marie Lannelongue Surgical Center (Université Paris-Sud), Le Plessis-Robinson, France.
Histopathology. 1995 Sep;27(3):257-62. doi: 10.1111/j.1365-2559.1995.tb00218.x.
Granular cell tumours rarely involve the lower respiratory tract. We report eight cases surgically resected at our institution. There were four females and four males, aged between 18 to 56 years (mean 40). One tumour associated with a peripheral lung adenocarcinoma was asymptomatic. The other lesions presented with obstructive pneumonitis (3 cases), haemoptysis (2), dyspnea (1) or cough (1). These tumours were tracheal (1) or bronchial (6) and one case was located in the lung parenchyma. Four cases were multicentric with associated lesions located in a bronchus (2), the oesophagus (1) or a mediastinal lymph node (1). All tumours, with the largest diameter ranging from 0.5-4.5 cm, were histologically invasive. The tumours were positive for S-100 protein, neuron specific enolase, KP1 (CD68) and vimentin. No tumour expressed desmin, keratin or p53 oncoprotein. Our study demonstrates that, in spite of marked anatomical and clinical polymorphism, the rare granular cell tumours of the lower respiratory tract have a constant histological appearance. Our observations confirm that large tumours (> 8-10 mm) usually extend beyond the tracheo-bronchial cartilages and, therefore, only surgical treatment may avoid recurrence.
颗粒细胞瘤很少累及下呼吸道。我们报告了在我院手术切除的8例病例。其中4例女性，4例男性，年龄在18至56岁之间（平均40岁）。1例与周围型肺腺癌相关的肿瘤无症状。其他病变表现为阻塞性肺炎（3例）、咯血（2例）、呼吸困难（1例）或咳嗽（1例）。这些肿瘤位于气管（1例）或支气管（6例），1例位于肺实质。4例为多中心性，相关病变位于支气管（2例）、食管（1例）或纵隔淋巴结（1例）。所有肿瘤最大直径为0.5 - 4.5 cm，组织学上均具有侵袭性。肿瘤S - 100蛋白、神经元特异性烯醇化酶、KP1（CD68）和波形蛋白呈阳性。无肿瘤表达结蛋白、角蛋白或p53癌蛋白。我们的研究表明，尽管存在明显的解剖学和临床多态性，但罕见的下呼吸道颗粒细胞瘤具有恒定的组织学表现。我们的观察结果证实，大肿瘤（> 8 - 10 mm）通常会超出气管支气管软骨，因此，只有手术治疗才能避免复发。
