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一名患有颗粒细胞支气管源性肿瘤的青少年:一例罕见病例报告及文献综述。

An Adolescent With a Granular Cell Bronchogenic Tumor: A Rare Case Report and Review of the Literature.

作者信息

Şambel Irmak Tanal, Başaran Abdurrahman Erdem, Bankoğlu Parlak Betül, Ağca Cengiz Didar, Özbudak İrem Hicran, Bingöl Ayşen

机构信息

Department of Pediatrics, Division of Pulmonology, Akdeniz University Faculty of Medicine, Antalya, Turkey.

Department of Pathology, Akdeniz University Faculty of Medicine, Antalya, Turkey.

出版信息

Clin Med Insights Pediatr. 2025 Sep 9;19:11795565251366784. doi: 10.1177/11795565251366784. eCollection 2025.

Abstract

Primary pulmonary tumors are rare in pediatric patients, and benign types are more frequently observed than malignant ones. Granular cell tumors (GCTs), of neuroectodermal origin, are uncommon in the lungs and especially rare in children. We report a case of a 16-year-old female with persistent respiratory symptoms initially diagnosed as asthma, who was ultimately found to have a bronchial granular cell tumor. The diagnosis was confirmed histopathologically, and the lesion was removed via rigid bronchoscopy. We also provide a review of the literature focusing on pediatric pulmonary GCTs. Granular cell tumors should be considered in the differential diagnosis of adolescents with persistent respiratory symptoms unresponsive to medical therapy. Early imaging and bronchoscopy can assist in timely diagnosis and lung-sparing treatment.

摘要

原发性肺肿瘤在儿科患者中较为罕见,良性类型比恶性类型更常见。神经外胚层起源的颗粒细胞瘤(GCTs)在肺部并不常见,在儿童中尤为罕见。我们报告一例16岁女性,有持续呼吸道症状,最初诊断为哮喘,最终发现患有支气管颗粒细胞瘤。经组织病理学确诊,通过硬支气管镜切除病变。我们还提供了一篇聚焦于儿童肺GCTs的文献综述。对于有持续呼吸道症状且药物治疗无效的青少年,鉴别诊断时应考虑颗粒细胞瘤。早期影像学检查和支气管镜检查有助于及时诊断和保留肺组织的治疗。

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本文引用的文献

1
Breast granular cell tumor: A case report and review of literature.乳腺颗粒细胞瘤:一例病例报告及文献复习
Radiol Case Rep. 2024 Jul 27;19(10):4358-4362. doi: 10.1016/j.radcr.2024.07.012. eCollection 2024 Oct.
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A case of bronchial granular cell tumor in a pediatric patient.一名儿科患者的支气管颗粒细胞瘤病例。
Clin Imaging. 2017 May-Jun;43:15-18. doi: 10.1016/j.clinimag.2017.01.008. Epub 2017 Jan 25.
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World J Surg Oncol. 2003 Oct 21;1(1):22. doi: 10.1186/1477-7819-1-22.
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