Sekhar G C, Nagarajan R
L.V. Prasad Eye Institute, Hyderabad.
Indian J Ophthalmol. 1995 Mar;43(1):23-6.
Tamoxifen is an antioestrogen drug used widely in the management of oestrogen-dependent metastatic breast carcinoma. A number of ocular complications have been described secondary to tamoxifen therapy. We report two patients, one of whom had superior ophthalmic vein thrombosis and the other who had painful proptosis and acute angle-closure glaucoma with choroidal detachment secondary to tamoxifen therapy, both of which have not been reported earlier. In both patients the signs and symptoms resolved rapidly after the discontinuation of tamoxifen therapy. Awareness of the ocular toxicity of tamoxifen is essential as prompt withdrawal can result in resolution of most of the complications.
他莫昔芬是一种抗雌激素药物，广泛用于雌激素依赖性转移性乳腺癌的治疗。已报道了一些他莫昔芬治疗继发的眼部并发症。我们报告了两名患者，其中一名患有眼上静脉血栓形成，另一名患有疼痛性眼球突出和急性闭角型青光眼伴脉络膜脱离，这两种情况均继发于他莫昔芬治疗，且此前均未被报道过。两名患者在停用他莫昔芬治疗后，体征和症状迅速缓解。认识到他莫昔芬的眼部毒性至关重要，因为及时停药可使大多数并发症得到缓解。
