Ersoz Mehmet Giray, Arf Serra, Karacorlu Murat, Hocaoglu Mumin, Muslubas Isil Sayman
Ophthalmic Surg Lasers Imaging Retina. 2017 Oct 1;48(10):838-842. doi: 10.3928/23258160-20170928-10.
Pachychoroid pigment epitheliopathy (PPE) is considered to be a forme fruste of central serous chorioretinopathy. Tamoxifen (Soltamax; Midatech Pharma, Raleigh, NC) has an anti-estrogenic effect on cytoplasmic estrogen receptors. Serum total testosterone, cortisol, and cortisone levels increase during tamoxifen therapy. Tamoxifen may cause hormone disturbance leading to the development of disorders in the pachychoroid spectrum. The authors present two cases of PPE associated with tamoxifen therapy. A 65-year-old woman (Patient 1) and a 52-year-old woman (Patient 2) had a recent history of tamoxifen therapy. PPE lesions were seen in both eyes of Patient 1 and in the right eye of Patient 2. [Ophthalmic Surg Lasers Imaging Retina. 2017;48:838-842.].
厚脉络膜色素上皮病变（PPE）被认为是中心性浆液性脉络膜视网膜病变的一种顿挫型。他莫昔芬（Soltamax；Midatech Pharma，罗利，北卡罗来纳州）对细胞质雌激素受体具有抗雌激素作用。在他莫昔芬治疗期间，血清总睾酮、皮质醇和可的松水平会升高。他莫昔芬可能会导致激素紊乱，进而引发厚脉络膜谱系疾病。作者报告了两例与他莫昔芬治疗相关的PPE病例。一名65岁女性（患者1）和一名52岁女性（患者2）近期有他莫昔芬治疗史。在患者1的双眼以及患者2的右眼中均发现了PPE病变。[《眼科手术、激光与视网膜成像》。2017；48：838 - 842。]
