肺炎链球菌对β-内酰胺类抗生素体外耐药性的产生
In-vitro development of resistance to beta-lactam antibiotics in Streptococcus pneumoniae.
作者信息
Carsenti-Etesse H, Durant J, De Salvador F, Bensoussan M, Bensoussan F, Pradier C, Thabaut A, Dellamonica P
机构信息
Archet Hospital, Nice University, France.
出版信息
J Antimicrob Chemother. 1995 Aug;36(2):417-23. doi: 10.1093/jac/36.2.417.
PMID:8522472
Abstract
Selection of resistant mutants was induced in broth by exposing pneumococci to serial sub-inhibitory concentrations of various beta-lactam antibiotics. Aminopenicillins selected for resistance to themselves and to cephalosporins although cephalosporins tended to select for resistance to their own class, with the exception of cefixime which seems to select cross-resistant organisms.
摘要
通过将肺炎球菌暴露于各种β-内酰胺抗生素的系列亚抑制浓度下，在肉汤中诱导耐药突变体的产生。氨基青霉素会筛选出对自身以及头孢菌素耐药的菌株，尽管头孢菌素倾向于筛选出对其自身类别耐药的菌株，但头孢克肟似乎会筛选出具有交叉耐药性的生物体。
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