Borosková Z, Soltys J, Benková M
Parasitological Institute SAS, Kosice, Slovak Republic.
J Helminthol. 1995 Sep;69(3):187-94. doi: 10.1017/s0022149x00014139.
The subchronic effect of mercury on selected immunological parameters was studied in guinea pigs with experimental Ascaris suum infection. HgC1(2) given for 28 days reduced significantly T- and B-cell populations in the lymphoid organs and the phagocytic ability of peritoneal macrophages. The subsequent infection of HgC1(2)-intoxicated animals elevated the studied immunological parameters, but in comparison with infected non-intoxicated guinea pigs they remained significantly suppressed. The mercury compound in infection stressed animals caused a slight alteration of the complement CH50 and AH50 activity. The specific circulating antibody level in infected and HgC1(2) treated animals rose a little by day 12 p.i. and then again decreased significantly, compared with untreated guinea pigs. The mean intensity of infection with migrating Ascaris larvae in HgC1(2)-treated animals increased by 15%, compared with controls.
在感染实验性猪蛔虫的豚鼠中研究了汞对选定免疫参数的亚慢性影响。给予HgC1₂ 28天可显著降低淋巴器官中的T细胞和B细胞数量以及腹膜巨噬细胞的吞噬能力。随后对HgC1₂中毒动物进行感染可提高所研究的免疫参数，但与未中毒的感染豚鼠相比，这些参数仍受到显著抑制。感染应激动物体内的汞化合物导致补体CH50和AH50活性略有改变。与未处理的豚鼠相比，感染且经HgC1₂处理的动物体内特异性循环抗体水平在感染后第12天略有上升，随后再次显著下降。与对照组相比，HgC1₂处理动物体内迁移性蛔虫幼虫的平均感染强度增加了15%。
