Borosková Z, Soltýs J, Benková M
Institute of Parasitology, Slovak Academy of Sciences, Kosice, Slovak Republic.
Vet Med (Praha). 1996 Jan;41(1):13-8.
A subchronic effect of copper on selected immunological parameters was studied in guinea pigs with experimental ascariosis (Ascaris suum). CuSO4 given orally for 28 days moderately increased T and B cells in the animal lymphoid organs. CH50 and AH50 complement levels remained unchanged during CuSO4 administration. A subsequent infection of subchronically intoxicated guinea pigs caused a repeated insignificant stimulation of B cell values while the percentage of T cells was not increased. On the contrary, the complement levels increased significantly in intoxicated infected animals, namely CH50 levels from day 5 to day 15 and AH50 levels from day 1 to day 7 post infection. No statistically significant differences were observed in comparison with infected non-intoxicated guinea pigs. The lean intensity of infection evoked by A. suum larvae migrating in the lungs of intoxicated animals was 29% lower than in control.
在患有实验性蛔虫病（猪蛔虫）的豚鼠中研究了铜对选定免疫参数的亚慢性影响。口服硫酸铜28天适度增加了动物淋巴器官中的T细胞和B细胞。在给予硫酸铜期间，CH50和AH50补体水平保持不变。随后对亚慢性中毒的豚鼠进行感染，导致B细胞值再次出现无显著意义的刺激，而T细胞百分比没有增加。相反，中毒感染动物的补体水平显著升高，即在感染后第5天至第15天CH50水平升高，感染后第1天至第7天AH50水平升高。与未中毒的感染豚鼠相比，未观察到统计学上的显著差异。中毒动物肺部猪蛔虫幼虫引起的感染强度比对照组低29%。
