Viagappan M, Kelsey M C
Public Health Laboratory, St George's Hospital, Tooting, London, UK.
J Hosp Infect. 1995 Jul;30(3):217-23. doi: 10.1016/s0195-6701(95)90317-8.
The source of coagulase-negative staphylococci (CNS) isolated from blood cultures and thought to be contaminants was investigated over a two month period. Isolates recovered from swabs taken from patients, doctors and laboratory staff were compared with the blood culture patient isolate in an attempt to identify the source of contamination. Six hundred and ninety-six blood culture sets were received of which 28 were contaminated with CNS. Nineteen of these blood cultures had sufficient data to be included in this study. Six were matched to isolates from the patient's skin and none to the medical or laboratory staff. Major differences in the antibiograms were seen between the patients, medical and laboratory staff. Organisms from patients and medical staff were more likely to have multiple antibiotic resistances. It appears that the most important source of CNS contamination of blood cultures processed in a semi-automated manner is the patient's own skin flora.
在两个月的时间里，对从血培养中分离出的、被认为是污染物的凝固酶阴性葡萄球菌（CNS）的来源进行了调查。从患者、医生和实验室工作人员身上采集的拭子中分离出的菌株，与血培养患者分离株进行了比较，以试图确定污染源。共收到696套血培养样本，其中28套被CNS污染。其中19套血培养有足够的数据可纳入本研究。6套与患者皮肤分离株匹配，与医护人员或实验室工作人员的分离株均不匹配。患者、医护人员和实验室工作人员的抗菌谱存在重大差异。患者和医护人员的菌株更有可能具有多重抗生素耐药性。看来，半自动处理的血培养中CNS污染的最重要来源是患者自身的皮肤菌群。
