肠胃炎患者的血浆硝酸盐浓度和尿硝酸盐排泄量

Plasma nitrate concentration and urinary nitrate excretion in patients with gastroenteritis.

作者信息

Dykhuizen R S, Copland M, Smith C C, Douglas G, Benjamin N

机构信息

Infection Unit City Hospital Aberdeen, U.K.

出版信息

J Infect. 1995 Jul;31(1):73-5. doi: 10.1016/s0163-4453(95)91643-1.

DOI:10.1016/s0163-4453(95)91643-1

PMID:8522841

Abstract

The concentration of nitrate (the stable oxidation product of nitric oxide) in plasma and its excretion in urine was measured in 20 patients with a diagnosis of gastroenteritis. On day 1 of the illness plasma nitrate concentration was significantly elevated compared with a healthy control population (92.7 +/- 17.0 mumol/l vs. 33.1 +/- 1.6 mumol/l; P < 0.001) and continued to be elevated on days 2 and 3. Urinary nitrate excretion was also elevated. The plasma nitrate concentration correlated with disease severity as assessed by stool frequency and plasma urea concentration. Plasma nitrate concentration may be a sensitive and clinically useful indicator of severity of gastroenteritis.

摘要

对20例诊断为肠胃炎的患者测量了血浆中硝酸盐（一氧化氮的稳定氧化产物）的浓度及其尿排泄量。患病第1天，与健康对照人群相比，血浆硝酸盐浓度显著升高（92.7±17.0μmol/L对33.1±1.6μmol/L；P<0.001），并在第2天和第3天持续升高。尿硝酸盐排泄量也升高。血浆硝酸盐浓度与通过大便频率和血浆尿素浓度评估的疾病严重程度相关。血浆硝酸盐浓度可能是肠胃炎严重程度的一个敏感且临床有用的指标。