Miyamoto H, Hata E, Sakao Y, Harada R, Hamada T
Department of Surgery, Mitsui Memorial Hospital, Tokyo, Japan.
Nihon Kyobu Geka Gakkai Zasshi. 1995 Nov;43(11):1804-9.
Since 1983, 421 patients have been treated for lung cancer at this institute. Since 1988, neck lymph node dissection (11 cases) and new extended lymphadenectomy through a collar incision and median sternotomy (22 cases) have been conducted. Indications for this new radical operation are scalene, supraclavicular or highest mediastinal node involvement, or superior pulmonary sulcus carcinoma, in patients aged 70 or less without distant metastasis and NSCLC. No major complications and operative mortality were encountered in this study. Patients with scalene or supraclavicular node involvement showed poor prognosis. Postsurgical local recurrence was frequent. Whether resection in N3 disease should be conducted or not, remains a point of controversy. The authors consider that lymphadenectomy should be conducted more extensively. A significant better survival of N2 disease and satisfactory prognosis of patients without metastasis of cervical lymph nodes demonstrates the effectiveness of neck lymph node dissection in the present superradical operation for lung cancer.
自1983年以来,该研究所共治疗了421例肺癌患者。自1988年起,开展了颈部淋巴结清扫术(11例)以及通过领口切口和正中胸骨切开术进行的新的扩大淋巴结切除术(22例)。这项新的根治性手术的适应证为:年龄在70岁及以下、无远处转移的非小细胞肺癌患者,伴有斜角肌、锁骨上或最高纵隔淋巴结受累,或肺上沟癌。本研究未出现重大并发症和手术死亡情况。伴有斜角肌或锁骨上淋巴结受累的患者预后较差,术后局部复发频繁。N3期疾病是否应进行手术切除仍存在争议。作者认为应更广泛地进行淋巴结清扫。N2期疾病患者生存率显著提高,且无颈部淋巴结转移患者预后良好,这表明在目前的肺癌超根治性手术中颈部淋巴结清扫术是有效的。