Leblhuber F, Peichl M, Neubauer C, Reisecker F, Steinparz F X, Windhager E, Maschek W
Department of Gerontology, Landesnervenklinik Wagner-Jauregg Linz, Austria.
J Neurol Sci. 1995 Sep;132(1):76-9. doi: 10.1016/0022-510x(95)00114-h.
Serum levels of dehydroepiandrosterone sulfate (DHEAS), known to antagonize metabolic effects of glucocorticoids in animals, and cortisol (CRT), already shown to be related to cognitive dysfunction in man and animals, were measured in 11 drug-free male subjects with definite Huntington's chorea (HC) and in 25 age-matched male normal controls. Statistical difference was found between DHEAS serum levels (p < 0.05), CRT levels (p < 0.05) and the DHEAS/CRT ratio (p < 0.01) of HC subjects and normal individuals. These findings may indicate a dysfunction of the hypothalamic-pituitary-adrenal axis (HPAA) and possibly suggest a role of DHEAS as an antiglucocorticoid in HC.
在11名确诊为亨廷顿舞蹈症（HC）的未服用药物的男性受试者以及25名年龄匹配的男性正常对照者中，检测了硫酸脱氢表雄酮（DHEAS）和皮质醇（CRT）的血清水平。已知DHEAS可拮抗动物体内糖皮质激素的代谢作用，而CRT已被证明与人类和动物的认知功能障碍有关。HC受试者与正常个体的DHEAS血清水平（p < 0.05）、CRT水平（p < 0.05）以及DHEAS/CRT比值（p < 0.01）存在统计学差异。这些发现可能表明下丘脑-垂体-肾上腺轴（HPAA）功能障碍，并可能提示DHEAS作为抗糖皮质激素在HC中的作用。
