Osmanagaoglu K, Kuyvenhoven J, Dierckx R A, Hamers J, Cuvelier C, Uyttendaele D, Simons M
Department of Nuclear Medicine, University Hospital, Ghent, Belgium.
J Nucl Med. 1995 Dec;36(12):2239-42.
We present the findings on 201Tl and 99mTc-MDP scintigraphy in three patients suffering from heterotopic ossification (two patients presenting with myositis ossificans and one patient presenting with juxta-articular ossification in combination with myositis ossificans). Since resection of the lesions has to be delayed until stabilization, 99mTc-MDP is often used as a parameter of lesional activity, although it is not optimal. For this clinical problem, we evaluated 201Tl scintigraphy as a marker of metabolic activity. In addition to the well-documented uptake of 99mTc-MDP, marked accumulation of 201Tl was observed in all heterotopic ossification sites. Hence, our results support the use of 201Tl scintigraphy in the therapeutic management and monitoring of conditions associated with ectopic ossification. On the other hand, although myositis ossificans is sometimes clinically, radiographically and even histologically confused with extraosseous osteogenic sarcoma, 201Tl accumulation may not be a helpful factor in the differential diagnosis due to the presence of tracer accumulation in both disorders.
我们展示了3例异位骨化患者的铊-201（²⁰¹Tl）和锝-99m亚甲基二膦酸盐（⁹⁹ᵐTc-MDP）骨闪烁显像结果（2例为骨化性肌炎，1例为关节旁骨化合并骨化性肌炎）。由于病变切除必须推迟到病情稳定后进行，尽管⁹⁹ᵐTc-MDP并非最佳选择，但它常被用作病变活动的指标。针对这一临床问题，我们评估了²⁰¹Tl骨闪烁显像作为代谢活性标志物的情况。除了⁹⁹ᵐTc-MDP摄取已得到充分记录外，在所有异位骨化部位均观察到²⁰¹Tl的明显积聚。因此，我们的结果支持将²⁰¹Tl骨闪烁显像用于与异位骨化相关疾病的治疗管理和监测。另一方面，尽管骨化性肌炎有时在临床、影像学甚至组织学上与骨外骨肉瘤相混淆，但由于两种疾病均存在示踪剂积聚，²⁰¹Tl积聚可能对鉴别诊断并无帮助。
