Wierzbicki A S, Nimmo L, Feher M D, Cox A, Foxton J, Lant A F
Department of Chemical Pathology, Chelsea and Westminster Hospital, London, UK.
J Hum Hypertens. 1995 Aug;9(8):671-3.
Angiotensin converting enzyme (ACE) genotypes have been associated with hypertension in the general population. However, the relation of ACE genotype to the prevalence of hypertension in diabetic populations is less clear. This study investigated ACE genotypes in 100 patients with diabetes mellitus, of whom 41 were on anti-hypertensive medication. A significant association was found between the presence of the ACE-D allele and hypertension in both the overall diabetic group (D = 0.66, P < 0.01) and in the subset of diabetics who had non-insulin-dependent diabetes (D = 0.69, P < 0.001). There was no correlation of ACE genotype with hypertension in insulin-dependent diabetes (D = 0.57).
血管紧张素转换酶（ACE）基因型与普通人群的高血压有关。然而，ACE基因型与糖尿病患者中高血压患病率的关系尚不清楚。本研究调查了100例糖尿病患者的ACE基因型，其中41例正在接受抗高血压药物治疗。在整个糖尿病组（D = 0.66，P < 0.01）以及非胰岛素依赖型糖尿病患者亚组（D = 0.69，P < 0.001）中，均发现ACE-D等位基因的存在与高血压之间存在显著关联。在胰岛素依赖型糖尿病患者中，ACE基因型与高血压无相关性（D = 0.57）。
