Yang C C, Hwang S F, Chou M M, Deng J F
Department of Medicine, Veterans General Hospital, Taipei, Taiwan, R.O.C.
J Toxicol Clin Toxicol. 1995;33(6):713-6. doi: 10.3109/15563659509010635.
Metobromuron, a substituted urea herbicide, is widely used for control of grasses and broad-leaved weeds in Taiwan. Major systemic toxicity has not been reported following poisoning. A 22-year-old woman at 36 weeks of gestation was admitted to the emergency department three hours after ingestion of a mixture of 25% metobromuron and 25% metolachlor. Though stable initially, she developed central cyanosis 12 hours later. Emergent cesarean section was considered but administration of intravenous methylene blue readily reversed the cyanosis and prevented the operation. Recurrent cyanosis did not develop. Normal vaginal delivery occurred 17 days after the poisoning. Follow-up for four years revealed normal growth of the child. Metobromuron poisoning, like other urea herbicides, may cause methemoglobinemia via its hydrolysis products. Administration of methylene blue is effective treatment and should be considered in the treatment of methemoglobinemia following urea herbicide poisoning.
甲氧隆是一种取代脲类除草剂，在台湾被广泛用于防治禾本科杂草和阔叶杂草。中毒后尚未报告有主要的全身毒性。一名妊娠36周的22岁女性在摄入25%甲氧隆和25%异丙甲草胺的混合物三小时后被送往急诊科。虽然最初情况稳定，但12小时后她出现了中枢性发绀。考虑进行紧急剖宫产，但静脉注射亚甲蓝后迅速逆转了发绀，避免了手术。未再出现反复发绀。中毒17天后正常阴道分娩。四年的随访显示孩子生长正常。甲氧隆中毒与其他脲类除草剂一样，可能通过其水解产物导致高铁血红蛋白血症。静脉注射亚甲蓝是有效的治疗方法，在脲类除草剂中毒导致高铁血红蛋白血症的治疗中应予以考虑。
