泡沫病毒载体
Foamy virus vectors.
作者信息
Russell D W, Miller A D
机构信息
Fred Hutchinson Cancer Research Center, Seattle, Washington 98104, USA.
出版信息
J Virol. 1996 Jan;70(1):217-22. doi: 10.1128/JVI.70.1.217-222.1996.
Abstract
Human foamy virus (HFV) is a retrovirus of the spumavirus family. We have constructed vectors based on HFV that encode neomycin phosphotransferase and alkaline phosphatase. These vectors are able to transduce a wide variety of vertebrate cells by integration of the vector genome. Unlike vectors based on murine leukemia virus, HFV vectors are not inactivated by human serum, and they transduce stationary-phase cultures more efficiently than murine leukemia virus vectors. These properties, as well as their large packaging capacity, make HFV vectors promising gene transfer vehicles.
摘要
人类泡沫病毒（HFV）是泡沫病毒科的一种逆转录病毒。我们构建了基于HFV的载体，这些载体编码新霉素磷酸转移酶和碱性磷酸酶。通过载体基因组的整合，这些载体能够转导多种脊椎动物细胞。与基于鼠白血病病毒的载体不同，HFV载体不会被人血清灭活，并且它们比鼠白血病病毒载体更有效地转导静止期培养物。这些特性以及它们较大的包装容量，使得HFV载体成为有前景的基因转移载体。
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The human foamy virus internal promoter directs the expression of the functional Bel 1 transactivator and Bet protein early after infection.人泡沫病毒内部启动子在感染后早期指导功能性Bel 1反式激活因子和Bet蛋白的表达。
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Adeno-associated virus vectors preferentially transduce cells in S phase.腺相关病毒载体优先转导处于S期的细胞。
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Nuclear localization of foamy virus Gag precursor protein.泡沫病毒Gag前体蛋白的核定位
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