Ito Y, Uehara T, Fukuchi K, Tsujimura E, Morozumi T, Kusuoka H, Nishimura T
Division of Tracer Kinetics, Osaka University Medical School, Japan.
Kaku Igaku. 1995 Oct;32(10):1117-23.
During mild to moderate ischemia, glycolytic flux is enhanced and free fatty acid uptake is reduced in proportion to the reduction in mitochondrial metabolism. We considered that mild exercise may induce the reduction of 123I-BMIPP, reflecting myocardial fatty acid metabolism, in ischemic myocardium compared to normal myocardium. Therefore, mild exercise 123I-BMIPP myocardial imaging was carried out to detect myocardial ischemia in 2 cases of ischemic heart disease. Mild exercise was performed using a bicycle ergometer with 25-50 W loading. At seven minutes before cessation of exercise, 111 MBq of 123I-BMIPP was injected. Case 1 was a 12 year-old boy with Kawasaki's disease. The study showed a reduction of mild exercise 123I-BMIPP uptake in the anteroseptal wall. In contrast, stress 201T1 myocardial imaging did not show perfusion defect in the anteroseptal wall. Case 2 was a 64 year-old female with triple vessels disease. Mild exercise 123I-BMIPP myocardial imaging showed similar with those of stress 99mTc-sestamibi. We conclude that mild exercise 123I-BMIPP myocardial SPECT may be a sensitive method to detect myocardial ischemia.
在轻至中度缺血期间，糖酵解通量增强，游离脂肪酸摄取量与线粒体代谢的减少成比例降低。我们认为，与正常心肌相比，轻度运动可能会导致缺血心肌中反映心肌脂肪酸代谢的123I-BMIPP减少。因此，对2例缺血性心脏病患者进行了轻度运动123I-BMIPP心肌显像以检测心肌缺血。使用负荷为25-50W的自行车测力计进行轻度运动。在运动停止前7分钟，注射111MBq的123I-BMIPP。病例1是一名患有川崎病的12岁男孩。研究显示前间隔壁轻度运动123I-BMIPP摄取减少。相比之下，负荷201T1心肌显像未显示前间隔壁灌注缺损。病例2是一名患有三支血管疾病的64岁女性。轻度运动123I-BMIPP心肌显像结果与负荷99mTc-司他米比显像结果相似。我们得出结论，轻度运动123I-BMIPP心肌SPECT可能是检测心肌缺血的一种敏感方法。
