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[磷脂酰肌醇特异性磷脂酶C(PI-PLC)在单核细胞增生李斯特菌和无害李斯特菌分化中的作用]

[Phosphatidylinositol specific phospholipase C (PI-PLC) in differentiation of Listeria monocytogenes and Listeria innocua].

作者信息

Pachelska M, Rózalska B, Smola J, Rudnicka W

机构信息

Zakład Biologii Infekcyjnej Uniwersytetu Lódzkiego.

出版信息

Med Dosw Mikrobiol. 1995;47(1-2):17-23.

PMID:8523967
Abstract

Listeria strains were investigated as regard: the production of PI-PLC and lecytinase, haemolytic and CAMP activity survival in mouse tissues. Although all the examined L. monocytogenes strains produced PI-PLC, they showed a very different activity of this enzyme. It was surprising that one of the four L. innocua strains demonstrated a weak activity of PI-PLC. L. monocytogenes bacteria with strong PI-PLC activity survived in mouse spleens for a much longer period of time than L. monocytogenes microbes with only a weak production of this enzyme. However, L. innocua bacteria producing some PI-PLC were quickly eliminated by infected mice.

摘要

对李斯特菌菌株进行了以下方面的研究

磷脂酰肌醇特异性磷脂酶C(PI-PLC)和卵磷脂酶的产生、溶血活性、CAMP活性以及在小鼠组织中的存活情况。尽管所有检测的单核细胞增生李斯特菌菌株都产生PI-PLC,但它们该酶的活性差异很大。令人惊讶的是,四种无害李斯特菌菌株之一表现出较弱的PI-PLC活性。PI-PLC活性强的单核细胞增生李斯特菌在小鼠脾脏中的存活时间比该酶产生较弱的单核细胞增生李斯特菌微生物长得多。然而,产生一些PI-PLC的无害李斯特菌会被感染的小鼠迅速清除。

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