Rémy C, Grand S, Laï E S, Belle V, Hoffmann D, Berger F, Estève F, Ziegler A, Le Bas J F, Benabid A L
Unité IRM, INSERM U318, Centre Hospitalier Universitaire de Grenoble, Hôpital A. Michallon, France.
Magn Reson Med. 1995 Oct;34(4):508-14. doi: 10.1002/mrm.1910340404.
Five patients, each with a brain abscess, were examined by means of 1H MR spectroscopic imaging in vivo. The aspirated pus was analyzed in vitro by means of 1D and 2D COSY 1H MRS. In addition to resonance lines from compounds (lactate, alanine and lipids) often found in the spectra from intracranial tumors, resonance lines were detected from a number of markers of infectious involvement (acetate, succinate, and various amino acids). These results suggest that 1H MRS in vivo might contribute in establishing noninvasively a differential diagnosis between brain abscess and tumor.
对5例脑脓肿患者进行了活体¹H磁共振波谱成像检查。通过一维和二维COSY¹H磁共振波谱对抽出的脓液进行体外分析。除了在颅内肿瘤光谱中常见的化合物（乳酸、丙氨酸和脂质）的共振线外，还检测到了一些感染相关标志物（乙酸盐、琥珀酸盐和各种氨基酸）的共振线。这些结果表明，活体¹H磁共振波谱可能有助于无创地鉴别脑脓肿和肿瘤。
