Martínez-Pérez I, Moreno A, Alonso J, Aguas J, Conesa G, Capdevila A, Arús C
Department of Biochemistry and Molecular Biology, Autonomous University of Barcelona, Spain.
J Neurosurg. 1997 Apr;86(4):708-13. doi: 10.3171/jns.1997.86.4.0708.
Two cases of brain abscess were diagnosed by combining magnetic resonance spectroscopy (MRS) and magnetic resonance (MR) imaging. The resonances observed in vivo were assigned by means of an in vitro MRS study of the exudates extracted during surgical aspiration of the abscesses. The technique of MRS was demonstrated to be very powerful in the differential diagnosis of brain abscesses from other brain pathologies such as neoplasms. Amino acids, probably originating from extracellular proteolysis, and other compounds, such as acetate, arising from bacterial metabolism, were visible in the MRS spectra of the abscess, whereas they are not present in spectra of neoplasms. In this sense, MRS complemented the information provided by MR imaging to achieve a correct diagnosis of brain abscesses and could be added to routine MR examinations with only a small increase in cost and time.
通过结合磁共振波谱（MRS）和磁共振（MR）成像诊断出两例脑脓肿。通过对脓肿手术抽吸出的渗出物进行体外MRS研究，确定了体内观察到的共振峰。结果表明，MRS技术在鉴别脑脓肿与其他脑部病变（如肿瘤）方面非常有效。在脓肿的MRS谱中可见可能源于细胞外蛋白水解的氨基酸以及源于细菌代谢的其他化合物（如乙酸盐），而在肿瘤谱中则不存在这些物质。从这个意义上讲，MRS补充了MR成像提供的信息，从而实现了对脑脓肿的正确诊断，并且只需在成本和时间上稍有增加，就可添加到常规MR检查中。
