Hypothesis: spermine may be an important epidermal antioxidant.

Spermine has been identified as a potent antioxidant and an anti-inflammatory agent. The compound is present in all organisms and all organs. The concentration is exceptionally high in skin, and I propose that spermine constitutes a prime defence against radiation damage. This hypothesis is substantiated by the fact that ornithine decarboxylase (ODC), the rate-controlling enzyme of spermine biosynthesis, is induced by UVB-irradiation and oxidative stress. On the contrary, inhibition of ODC makes cells more sensitive to radiation damage. The antioxidative effect of spermine may be due to metal chelation and/or to prevention of superoxide generation from stimulated neutrophils. This paper reviews the antioxidative and anti-inflammatory effects of spermine, and suggests that spermine is an important antioxidant of epidermis.