Pavić Z, Pavić S
Institut za patofiziologiju, Medicinski fakultet, Banjaluka.
Med Pregl. 1995;48(7-8):231-3.
Thyroid function was evaluated in premenopausal (healthy controls n = 7, benign breast disease n = 59, primary breast cancer n = 7) and postmenopausal (healthy controls n = 8, benign breast disease n = 51, primary breast cancer n = 10) groups of female subjects. The following parameters were measured: T3, T4, FT3I, FT3I, T3U and TSH. Except significantly higher concentration of T3 in postmenopausal healthy controls (179.6 +/- 32.9 vs. 152.3 +/- 22.4 p < 0.05), in benign and malignant breast lesions there was not any significant deviation. T3U, FT3I and FT4I did not significantly differ in relation to menopausal status. Basal TSH level was premenopausally higher in all groups, but with statistically significant difference within the group of primary breast cancer (0.98 +/- 0.22 vs. 0.47 +/- 0.17 p < 0.05). Consequently, pathologic variations of thyroid hormones plasma level together with the changes of activities of thyrotropin cells could be a significant factor in premenopausal mammary tumorigenesis, while in benign breast lesions a possible relation between thyroid hormone instability and menopausal status was not identified.
对绝经前（健康对照组n = 7，良性乳腺疾病n = 59，原发性乳腺癌n = 7）和绝经后（健康对照组n = 8，良性乳腺疾病n = 51，原发性乳腺癌n = 10）的女性受试者组进行甲状腺功能评估。测量了以下参数：T3、T4、FT3I、FT4I、T3U和TSH。除绝经后健康对照组中T3浓度显著较高（179.6±32.9对152.3±22.4，p<0.05）外，良性和恶性乳腺病变中均未出现任何显著偏差。T3U、FT3I和FT4I在绝经状态方面无显著差异。所有组中基础TSH水平在绝经前均较高，但在原发性乳腺癌组内有统计学显著差异（0.98±0.22对0.47±0.17，p<0.05）。因此，甲状腺激素血浆水平的病理变化以及促甲状腺素细胞活性的改变可能是绝经前乳腺肿瘤发生的一个重要因素，而在良性乳腺病变中未发现甲状腺激素不稳定性与绝经状态之间的可能关系。
