Veggiotti P, Colamaria V, Dalla Bernardina B, Martelli A, Mangione D, Lanzi G
Divisione di Neuropsichiatria Infantile, Fondazione Istituto Neurologico C Mondino IRCCS, Pavia, Italy.
Neurophysiol Clin. 1995;25(3):158-66. doi: 10.1016/0987-7053(96)80168-7.
There are few reports in the literature dealing with the association between mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) and epilepsia partialis continua (EPC) in children. We report the case of a child presenting with numerous stroke-like episodes associated with EPC which, despite therapy, were not controlled and aggravated the clinical condition of our patient. We present the neuroradiological, biochemical, genetic and muscle biopsy findings, and EEG characteristics, with attention to polygraphic recordings which were done during wake and sleep periods. We consider the correlation with other possible etiological factors relating to EPC and in particular coinvolvement of the basal ganglia as a cause of EPC in our patient.
文献中很少有关于儿童线粒体肌病、脑病、乳酸性酸中毒和卒中样发作（MELAS）与持续性部分性癫痫（EPC）之间关联的报道。我们报告了一例患有大量与EPC相关的卒中样发作的儿童病例，尽管进行了治疗，但发作未得到控制，且加重了患者的临床状况。我们展示了神经放射学、生化、遗传学和肌肉活检结果以及脑电图特征，尤其关注了在清醒和睡眠期间进行的多导记录。我们考虑了与EPC其他可能病因的相关性，特别是基底神经节受累作为我们患者EPC病因的情况。
