• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Structure of open promoter complexes with Escherichia coli RNA polymerase as revealed by the DNase I footprinting technique: compilation analysis.通过DNA酶I足迹技术揭示的大肠杆菌RNA聚合酶开放启动子复合物的结构：汇编分析
Nucleic Acids Res. 1995 Nov 25;23(22):4533-41. doi: 10.1093/nar/23.22.4533.
2
Factor-independent activation of Escherichia coli rRNA transcription. II. characterization of complexes of rrnB P1 promoters containing or lacking the upstream activator region with Escherichia coli RNA polymerase.大肠杆菌rRNA转录的因子非依赖性激活。II. 含有或缺乏上游激活区的rrnB P1启动子与大肠杆菌RNA聚合酶复合物的特性
J Mol Biol. 1991 Aug 5;220(3):569-83. doi: 10.1016/0022-2836(91)90101-b.
3
Non-canonical sequence elements in the promoter structure. Cluster analysis of promoters recognized by Escherichia coli RNA polymerase.启动子结构中的非典型序列元件。大肠杆菌RNA聚合酶识别的启动子的聚类分析。
Nucleic Acids Res. 1997 Dec 1;25(23):4703-9. doi: 10.1093/nar/25.23.4703.
4
Domain 1.1 of the sigma(70) subunit of Escherichia coli RNA polymerase modulates the formation of stable polymerase/promoter complexes.大肠杆菌RNA聚合酶σ（70）亚基的1.1结构域调节稳定的聚合酶/启动子复合物的形成。
J Mol Biol. 2001 Jun 8;309(3):561-72. doi: 10.1006/jmbi.2001.4690.
5
RNA chain initiation by Escherichia coli RNA polymerase. Structural transitions of the enzyme in early ternary complexes.大肠杆菌RNA聚合酶引发RNA链合成。早期三元复合物中酶的结构转变。
Biochemistry. 1989 Sep 19;28(19):7829-42. doi: 10.1021/bi00445a045.
6
Structural analysis of ternary complexes of Escherichia coli RNA polymerase. Deoxyribonuclease I footprinting of defined complexes.大肠杆菌RNA聚合酶三元复合物的结构分析。特定复合物的脱氧核糖核酸酶I足迹分析。
J Mol Biol. 1992 May 20;225(2):239-50. doi: 10.1016/0022-2836(92)90918-a.
7
Interactions between the cyclic AMP receptor protein and the alpha subunit of RNA polymerase at the Escherichia coli galactose operon P1 promoter.环腺苷酸受体蛋白与大肠杆菌半乳糖操纵子P1启动子处RNA聚合酶α亚基之间的相互作用。
Nucleic Acids Res. 1994 Oct 25;22(21):4375-80. doi: 10.1093/nar/22.21.4375.
8
Compilation and analysis of sigma(54)-dependent promoter sequences.σ⁵⁴ 依赖型启动子序列的汇编与分析
Nucleic Acids Res. 1999 Nov 15;27(22):4305-13. doi: 10.1093/nar/27.22.4305.
9
DNA footprints of the two kinetically significant intermediates in formation of an RNA polymerase-promoter open complex: evidence that interactions with start site and downstream DNA induce sequential conformational changes in polymerase and DNA.RNA聚合酶-启动子开放复合物形成过程中两个动力学上重要中间体的DNA足迹：与起始位点和下游DNA的相互作用诱导聚合酶和DNA顺序构象变化的证据。
J Mol Biol. 1998 Nov 6;283(4):741-56. doi: 10.1006/jmbi.1998.2129.
10
Development of RNA polymerase-promoter contacts during open complex formation.开放复合物形成过程中RNA聚合酶与启动子的相互作用的发展。
J Mol Biol. 1991 Aug 5;220(3):585-97. doi: 10.1016/0022-2836(91)90102-c.

引用本文的文献

1
Mycobacterial RNA polymerase forms unstable open promoter complexes that are stabilized by CarD.分枝杆菌RNA聚合酶形成不稳定的开放启动子复合物，这些复合物由CarD稳定。
Nucleic Acids Res. 2015 Jan;43(1):433-45. doi: 10.1093/nar/gku1231. Epub 2014 Dec 15.
2
Promoter-specific transcription inhibition in Staphylococcus aureus by a phage protein.噬菌体蛋白对金黄色葡萄球菌启动子特异性转录的抑制作用。
Cell. 2012 Nov 21;151(5):1005-16. doi: 10.1016/j.cell.2012.10.034.
3
Specific contacts of the -35 region of the galP1 promoter by RNA polymerase inhibit GalR-mediated DNA looping repression.galP1 启动子 -35 区的特定 RNA 聚合酶接触抑制 GalR 介导的 DNA 环回抑制。
Nucleic Acids Res. 2012 Nov 1;40(20):10064-72. doi: 10.1093/nar/gks796. Epub 2012 Aug 31.
4
Gene silencing H-NS paralogue StpA forms a rigid protein filament along DNA that blocks DNA accessibility.基因沉默 H-NS 旁系同源物 StpA 沿 DNA 形成刚性蛋白丝，阻止 DNA 可及性。
Nucleic Acids Res. 2012 Apr;40(8):3316-28. doi: 10.1093/nar/gkr1247. Epub 2011 Dec 19.
5
Analysis of RNA polymerase-promoter complex formation.RNA聚合酶-启动子复合物形成的分析。
Methods. 2009 Jan;47(1):13-24. doi: 10.1016/j.ymeth.2008.10.018. Epub 2008 Oct 24.
6
Sequence-independent upstream DNA-alphaCTD interactions strongly stimulate Escherichia coli RNA polymerase-lacUV5 promoter association.不依赖序列的上游DNA-αCTD相互作用强烈刺激大肠杆菌RNA聚合酶与lacUV5启动子的结合。
Proc Natl Acad Sci U S A. 2005 Jan 11;102(2):291-6. doi: 10.1073/pnas.0405814102. Epub 2004 Dec 30.
7
Binding of the C-terminal domain of the alpha subunit of RNA polymerase to the phage mu middle promoter.RNA聚合酶α亚基的C末端结构域与噬菌体μ中间启动子的结合。
J Bacteriol. 2004 Dec;186(23):7858-64. doi: 10.1128/JB.186.23.7858-7864.2004.
8
Purification and in vitro characterization of the Serratia marcescens NucC protein, a zinc-binding transcription factor homologous to P2 Ogr.粘质沙雷氏菌NucC蛋白的纯化及体外特性研究，NucC蛋白是一种与P2 Ogr同源的锌结合转录因子。
J Bacteriol. 2003 Mar;185(6):1808-16. doi: 10.1128/JB.185.6.1808-1816.2003.
9
Regulation of the Escherichia coli rrnB P2 promoter.大肠杆菌rrnB P2启动子的调控
J Bacteriol. 2003 Jan;185(1):28-34. doi: 10.1128/JB.185.1.28-34.2003.
10
Mode of DNA-protein interaction between the C-terminal domain of Escherichia coli RNA polymerase alpha subunit and T7D promoter UP element.大肠杆菌RNA聚合酶α亚基C末端结构域与T7D启动子上游元件之间的DNA-蛋白质相互作用模式
Nucleic Acids Res. 2001 Dec 15;29(24):4909-19. doi: 10.1093/nar/29.24.4909.

本文引用的文献

1
Involvement of the RNA polymerase alpha subunit C-terminal region in co-operative interaction and transcriptional activation with OxyR protein.RNA聚合酶α亚基C末端区域参与与OxyR蛋白的协同相互作用和转录激活。
Mol Microbiol. 1993 Mar;7(6):859-64. doi: 10.1111/j.1365-2958.1993.tb01176.x.
2
Compilation of E. coli mRNA promoter sequences.大肠杆菌信使核糖核酸启动子序列的汇编。
Nucleic Acids Res. 1993 Apr 11;21(7):1507-16. doi: 10.1093/nar/21.7.1507.
3
Effects of a single base-pair deletion in the bacteriophage lambda PRM promoter. Repression of PRM by repressor bound at OR2 and by RNA polymerase bound at PR.噬菌体λ PRM启动子中单碱基对缺失的影响。阻遏蛋白结合在OR2以及RNA聚合酶结合在PR时对PRM的抑制作用。
J Mol Biol. 1993 Jan 5;229(1):37-51. doi: 10.1006/jmbi.1993.1006.
4
E. coli RNA polymerase, deleted in the C-terminal part of its alpha-subunit, interacts differently with the cAMP-CRP complex at the lacP1 and at the galP1 promoter.在其α亚基的C末端部分缺失的大肠杆菌RNA聚合酶，在lacP1和galP1启动子处与cAMP-CRP复合物的相互作用不同。
Nucleic Acids Res. 1993 Jan 25;21(2):319-26. doi: 10.1093/nar/21.2.319.
5
A third recognition element in bacterial promoters: DNA binding by the alpha subunit of RNA polymerase.细菌启动子中的第三种识别元件：RNA聚合酶α亚基与DNA的结合。
Science. 1993 Nov 26;262(5138):1407-13. doi: 10.1126/science.8248780.
6
Interactions between the cyclic AMP receptor protein and the alpha subunit of RNA polymerase at the Escherichia coli galactose operon P1 promoter.环腺苷酸受体蛋白与大肠杆菌半乳糖操纵子P1启动子处RNA聚合酶α亚基之间的相互作用。
Nucleic Acids Res. 1994 Oct 25;22(21):4375-80. doi: 10.1093/nar/22.21.4375.
7
Interaction of bacterial RNA-polymerase with two different promoters of phage T7 DNA. Conformational analysis.细菌RNA聚合酶与噬菌体T7 DNA的两个不同启动子的相互作用。构象分析。
Biochim Biophys Acta. 1993 Mar 20;1172(3):251-61. doi: 10.1016/0167-4781(93)90211-u.
8
Multiple protein-DNA and protein-protein interactions are involved in transcriptional activation by MalT.多种蛋白质-DNA和蛋白质-蛋白质相互作用参与了MalT介导的转录激活过程。
Mol Microbiol. 1994 Oct;14(2):335-46. doi: 10.1111/j.1365-2958.1994.tb01294.x.
9
Transcription activation by the Escherichia coli cyclic AMP receptor protein. Receptors bound in tandem at promoters can interact synergistically.大肠杆菌环磷酸腺苷受体蛋白介导的转录激活。串联结合在启动子上的受体可发生协同相互作用。
J Mol Biol. 1994 Aug 19;241(3):341-52. doi: 10.1006/jmbi.1994.1511.
10
The Escherichia coli cysG promoter belongs to the 'extended -10' class of bacterial promoters.大肠杆菌cysG启动子属于细菌启动子的“扩展-10”类别。
Biochem J. 1993 Dec 15;296 ( Pt 3)(Pt 3):851-7. doi: 10.1042/bj2960851.

通过DNA酶I足迹技术揭示的大肠杆菌RNA聚合酶开放启动子复合物的结构：汇编分析

Structure of open promoter complexes with Escherichia coli RNA polymerase as revealed by the DNase I footprinting technique: compilation analysis.

作者信息

Ozoline O N, Tsyganov M A

机构信息

Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region, Russian Federation.

出版信息

Nucleic Acids Res. 1995 Nov 25;23(22):4533-41. doi: 10.1093/nar/23.22.4533.

DOI:10.1093/nar/23.22.4533
PMID:8524639
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC307422/
Abstract

Footprinting data for 33 open promoter complexes with Escherichia coli RNA polymerase, as well as 17 ternary complexes with different regulators, have been compiled using a computer program FUTPR. The typical and individual properties of their structural organization are analyzed. Promoters are subgrouped according to the extent of the polymerase contact area. A set of alternative sequence elements that could be responsible for RNA polymerase attachment in different promoter groups is suggested on the basis of their sequence homology near the hyperreactive sites. The model of alternative pathways used for promoter activation is discussed.

摘要

利用计算机程序FUTPR汇编了33个大肠杆菌RNA聚合酶开放启动子复合物以及17个与不同调节因子的三元复合物的足迹数据。分析了它们结构组织的典型和个体特性。启动子根据聚合酶接触区域的范围进行分组。基于它们在高反应性位点附近的序列同源性，提出了一组可能负责不同启动子组中RNA聚合酶附着的替代序列元件。讨论了用于启动子激活的替代途径模型。