Bowling T E
Department of Gastroenterology and Nutrition, Central Middlesex Hospital, London.
Proc Nutr Soc. 1995 Jul;54(2):579-90. doi: 10.1079/pns19950026.
So to summarize the key points: 1. concomitant antibiotic therapy, infected diets and possibly hypoalbuminaemia can lead to enteral-feeding-related diarrhoea; 2. the small intestinal responses to both intragastric and intraduodenal enteral feeding are normal and predictable; 3. there is an ascending colonic secretion during enteral feeding which is more profound during intragastric feeding; 4. the suppression of distal colonic motor activity occurs only during high-load feeding and is probably a secondary phenomenon to the hormonal and secretory responses; 5. peptide YY appears to be intrinsically bound up with the causation of the secretory effect; 6. the secretory effect is abolished by intracaecal SCFA.
综上所述，要点如下：1. 联合抗生素治疗、感染性饮食以及可能的低白蛋白血症可导致肠内喂养相关腹泻；2. 小肠对胃内和十二指肠内肠内喂养的反应正常且可预测；3. 肠内喂养期间升结肠会分泌，胃内喂养期间分泌更显著；4. 仅在高负荷喂养期间远端结肠运动活性受到抑制，这可能是激素和分泌反应的继发现象；5. 肽YY似乎与分泌效应的发生内在相关；6. 盲肠内短链脂肪酸可消除分泌效应。
