Jackson L, Branch R, Levine D, Ramsay L
Eur J Clin Pharmacol. 1977 Mar 11;11(3):177-9. doi: 10.1007/BF00606407.
The elimination half-life (T1/2) of canrenone, the principal unconjugated metabolite of spironolactone, was 59 h (range 32-105 h) in 5 patients with chronic liver disease and 37 h (range 19-48 h ) in 7 patients withcongestive heart failure. In comparison the T1/2 in normal subjects was 13.5-24 h in previous reports and 20.5 h in the present study, However there was no evidence of greater cumulation of canrenone in the plasma of those patients with a prolonged T1/2.
安体舒通的主要非结合代谢产物坎利酮在5例慢性肝病患者中的消除半衰期（T1/2）为59小时（范围32 - 105小时），在7例充血性心力衰竭患者中为37小时（范围19 - 48小时）。相比之下，先前报道中正常受试者的T1/2为13.5 - 24小时，本研究中为20.5小时。然而，没有证据表明T1/2延长的患者血浆中坎利酮有更大程度的蓄积。
