脂多糖A结合配体的多样性：脂多糖A单克隆抗体与重组杀菌/通透性增加蛋白23的比较
Diversity in lipid A binding ligands: comparison of lipid A monoclonal antibodies with rBPI23.
作者信息
Appelmelk B J, Qing A Y, Helmerhorst E J, Maaskant J J, Abraham P R, Thijs L G, MacLaren D M
机构信息
Free University, Department of Medical Microbiology, Amsterdam, The Netherlands.
出版信息
Prog Clin Biol Res. 1995;392:453-63.
PMID:8524952
Abstract
- Mabs with a high affinity for free lipid A do not bind when it is covalently linked, i.e. in the form of LPS. 2. Lipid A-binding Mabs may be divided into three categories: I. Monoreactive Mabs that bind to the hydrophillic backbone of lipid A II. Polyreactive Kdo Mabs III. Polyreactive Mabs that bind by hydrophobic interactions 3. rBPI23 binds either free or covalently linked lipid A.
摘要
- 对游离脂质A具有高亲和力的单克隆抗体在脂质A共价连接时（即脂多糖形式）不结合。2. 脂质A结合单克隆抗体可分为三类：I. 与脂质A亲水主链结合的单反应性单克隆抗体；II. 多反应性Kdo单克隆抗体；III. 通过疏水相互作用结合的多反应性单克隆抗体。3. rBPI23可结合游离或共价连接的脂质A。
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