Spriet A, Spriet C, Larousse C, Chigot D, Roux M, Simon P
Eur J Clin Pharmacol. 1977 Mar 11;11(3):181-92. doi: 10.1007/BF00606408.
A survey of tolerance of a drug, determined in private practice under "naturalistic" conditions by 591 physicians, and involving 22277 patients is presented. The procedure used in private practice to gather systematic information about reactions to the drug involved a system of data sheets with detachable cards for optical reading and computer analysis. The survey was conducted under the responsiblity at regional level of a team of scientific coordinators-hospital pharmacologists and poison control centres. Possible side effects were noticed in 13,82% of patients, a figure similar to known nocebo reactions. Tolerance was significantly related to sex, age, weight, geographical area, duration of treatment, association with other durgs and therapeutic result. When related to individual physicians, the overall number of side effects and the frequency of three of them in particular did not follow a binomial distribution; the rate of adverse reactions was significantly related to the number of years of practice of the physicians.
本文呈现了一项关于药物耐受性的调查，该调查由591名医生在“自然主义”条件下的私人诊所进行，涉及22277名患者。在私人诊所中用于收集有关药物反应的系统信息的程序，涉及一个带有可分离卡片的数据表系统，用于光学读取和计算机分析。该调查在一组科学协调员（医院药理学家和中毒控制中心）的区域层面负责下进行。13.82%的患者出现了可能的副作用，这一数字与已知的反安慰剂反应相似。耐受性与性别、年龄、体重、地理区域、治疗持续时间、与其他药物的联合使用以及治疗结果显著相关。当与个体医生相关时，副作用的总数以及其中三种副作用的频率尤其不遵循二项分布；不良反应的发生率与医生的执业年限显著相关。
