Taylor P M, Luna S P, Sear J W, Wheeler M J
Nuffield Department of Anaesthetics, John Radcliffe Hospital, University of Oxford.
Res Vet Sci. 1995 Jul;59(1):17-23. doi: 10.1016/0034-5288(95)90024-1.
Pharmacokinetics and some pharmacological effects of anaesthesia induced by a combination of detomidine, ketamine and guaiphenesin were investigated in eight ponies. Cardiopulmonary function was studied and plasma met-enkephalin, dynorphin, beta-endorphin, arginine vasopressin, adrenocorticotrophin, cortisol, 11-deoxycortisol and catecholamine concentrations were measured. The combination produced slight cardiorespiratory depression, hyperglycaemia and a reduction in haematocrit. There were no changes in plasma opioids, pituitary peptides or catecholamines. Plasma cortisol concentration decreased and plasma 11-deoxycortisol increased indicating a suppression of steroidogenesis. Steady state ketamine and guaiphenesin concentrations were attained during the infusion period, and ketamine concentrations likely to provide adequate analgesia for surgical operations were achieved (more than 2.2 micrograms ml-1). Steady state detomidine concentration was not attained. The ponies took on average 68 minutes to recover to standing and the recovery was uneventful.
在八匹小马中研究了右美托咪定、氯胺酮和愈创甘油醚联合诱导麻醉的药代动力学及一些药理作用。研究了心肺功能，并测定了血浆中蛋氨酸脑啡肽、强啡肽、β-内啡肽、精氨酸加压素、促肾上腺皮质激素、皮质醇、11-脱氧皮质醇和儿茶酚胺的浓度。该联合用药产生了轻微的心肺抑制、高血糖和血细胞比容降低。血浆阿片类物质、垂体肽或儿茶酚胺无变化。血浆皮质醇浓度降低，血浆11-脱氧皮质醇升高，表明类固醇生成受到抑制。在输注期间达到了氯胺酮和愈创甘油醚的稳态浓度，并且达到了可能为外科手术提供足够镇痛的氯胺酮浓度（超过2.2微克/毫升）。未达到右美托咪定的稳态浓度。小马平均需要68分钟恢复站立，恢复过程平稳。
