Flaherty D, Reid J, Welsh E, Monteiro A M, Lerche P, Nolan A
Department of Veterinary Clinical Studies, University of Glasgow.
Res Vet Sci. 1997 Mar-Apr;62(2):179-84. doi: 10.1016/s0034-5288(97)90143-0.
The pharmacodynamics of infusions of propofol alone (group 1) were compared with the pharmacodynamics of infusions of propofol and ketamine together (group 2) in eight ponies undergoing castration. Anaesthesia was induced with detomidine, 20 micrograms kg-1, followed by ketamine, 2.2 mg kg-1. Subsequently, a bolus dose of propofol, 0.5 mg kg-1, was administered intravenously to both groups, and an infusion of propofol was given for an average of 74 minutes to group 1, and an infusion of propofol and ketamine was given for 60 minutes to group 2. The mean (SD) infusion rates of propofol were 0.330 (0.050) mg kg-1 min-1 in group 1, and 0.124 (0.009) mg kg-1 in group 2, and the ketamine infusion rate was maintained constant at 40 micrograms kg-1 min-1. Arterial hypotension and marked respiratory depression were evident in some of the ponies receiving propofol alone, whereas in the ponies anaesthetised with propofol and ketamine, respiratory and cardiovascular parameters were well maintained. All the ponies in both groups recovered quickly from anaesthesia, with mean times to sternal recumbency and standing of 19.8 (8.0) minutes and 27.2 (7.4) minutes respectively for group 1 and 8.4 (3.2) min and 14.9 (10.1) minutes for group 2.
在八匹接受去势手术的小马中，比较了单独输注丙泊酚（第1组）与丙泊酚和氯胺酮联合输注（第2组）的药效学。用20微克/千克的右美托咪定诱导麻醉，随后给予2.2毫克/千克的氯胺酮。随后，两组均静脉注射0.5毫克/千克的丙泊酚推注剂量，第1组平均输注丙泊酚74分钟，第2组平均输注丙泊酚和氯胺酮60分钟。第1组丙泊酚的平均（标准差）输注速率为0.330（0.050）毫克/千克·分钟，第2组为0.124（0.009）毫克/千克，氯胺酮输注速率维持在40微克/千克·分钟不变。一些单独接受丙泊酚的小马出现明显的动脉低血压和显著的呼吸抑制，而在用丙泊酚和氯胺酮麻醉的小马中，呼吸和心血管参数维持良好。两组所有小马均迅速从麻醉中恢复，第1组平均恢复到胸卧姿势和站立的时间分别为19.8（8.0）分钟和27.2（7.4）分钟，第2组为8.4（3.2）分钟和14.9（10.1）分钟。
