Rivera T, Palma-Guzman R, Morales W
Departamento de Microbiología y Parasitología, Facultad de Medicina UNAN-León, Nicaragua.
Rev Inst Med Trop Sao Paulo. 1995 May-Jun;37(3):207-13. doi: 10.1590/s0036-46651995000300005.
With the aim of determining the prevalence, immunological profile, and knowing the electrocardiographic alterations, a clinical and seroepidemiological study of Chagas' disease was performed in three rural settlements located at the North, East and West of Nicaragua. Anti T. cruzi antibodies were searched by indirect immunofluorescence (IFI) and hemagglutination (IHA) in a total of 803 subjects. Seropositives and the same number of seronegatives, matched by age and sex, were included in a case-control design for the electrocardiographic assessment. Antibody prevalence was 13.1, 4.3 and 3.2% in the respective settlements. In the first two the immunological profile corresponds to that of an endemic zone of long standing, were transmission has decreased, and in the third the pattern is of a zone under control. Electrocardiographic changes compatible with Chagas' disease were found in seropositive individuals, but difference with control group was not statistically significant. It is concluded that the disease is endemic in the three settlements and the clinical aspect requires further evaluation, including additional cardiologic techniques.
为了确定查加斯病的患病率、免疫状况并了解心电图改变，在尼加拉瓜北部、东部和西部的三个农村定居点开展了一项关于查加斯病的临床和血清流行病学研究。通过间接免疫荧光法（IFI）和血凝试验（IHA）对总共803名受试者进行了抗克鲁斯锥虫抗体检测。在一项用于心电图评估的病例对照设计中，纳入了血清阳性者以及相同数量、年龄和性别匹配的血清阴性者。各定居点的抗体患病率分别为13.1%、4.3%和3.2%。在前两个定居点，免疫状况与一个长期存在的流行区相符，传播率已下降，而在第三个定居点，情况属于可控区域模式。在血清阳性个体中发现了与查加斯病相符的心电图变化，但与对照组的差异无统计学意义。得出的结论是，该病在这三个定居点呈地方性流行，临床情况需要进一步评估，包括采用更多的心脏检查技术。
