Feliziani V, Lattuada G, Parmiani S, Dall'Aglio P P
Ambulatorio di Allergologia Divisione Medicina, Ospedale Civile di Lanciano, Chieti, Italia.
Allergol Immunopathol (Madr). 1995 Sep-Oct;23(5):224-30.
Thirty-four patients suffering from rhinoconjunctivitis with or without asthma due to grass pollen, were submitted to sublingual immunotherapy according to a double blind placebo controlled experimental plan; eighteen patients received the active therapy, sixteen the placebo. A rush preseasonal treatment schedule was followed in order to reach the maintenance dose in 15 days with two administrations per day; the top dose reached was then administered three times a week until the end of the pollen season. The symptoms and drugs related to rhinoconjunctivitis and asthma were recorded by means of diary cards and grass pollen counts were performed during the season. The actively treated group showed a reduction of symptoms of rhinoconjunctivitis and asthma and a lower intake of drugs for the same symptoms; all these differences resulted to be statistically significant. No patient showed local or systemic side effects of any relevance. According to these results of our study, sublingual rush immunotherapy is clinically effective and because of the ease of handling, the shortness of the treatment, the absence of relevant side effects and the high compliance of the patient can be considered as an alternative to classic injective immunotherapy in grass pollen allergic patients.
34例因草花粉引起的伴有或不伴有哮喘的鼻结膜炎患者，按照双盲安慰剂对照实验方案接受舌下免疫治疗；18例患者接受活性治疗，16例接受安慰剂治疗。采用快速季前治疗方案，以便在15天内达到维持剂量，每天给药两次；然后将达到的最高剂量每周给药三次，直至花粉季节结束。通过日记卡记录与鼻结膜炎和哮喘相关的症状及药物使用情况，并在季节期间进行草花粉计数。积极治疗组的鼻结膜炎和哮喘症状有所减轻，相同症状的药物摄入量减少；所有这些差异均具有统计学意义。没有患者出现任何相关的局部或全身副作用。根据我们研究的这些结果，舌下快速免疫治疗在临床上是有效的，并且由于操作简便、治疗时间短、无相关副作用以及患者依从性高，可被视为草花粉过敏患者经典注射免疫治疗的替代方法。
