Blasco Casares F J, Saladie Roig J M
Department of Urology, Hospital Municipal de Badalona, Barcelona, Spain.
Arch Esp Urol. 1995 Oct;48(8):858-65.
To develop two experimental models in rats to study the ureter under conditions of total devascularization and denervation.
The ureter was autotransplanted as an integrated autologous free graft (IAFG) or abandoned in the retroperitoneum as a non integrated autologous free graft (NIAFG). Both models were compared with a normal group and a surgical control group. Sixty-two rats were randomly distributed: Normal ureter (NU) group (n = 20); surgical control, only ureterolysis (SC) group (n = 15); abandoned ureter as NIAFG (AU) group (n = 13); reimplanted ureter as IAFG (RU) group (n = 14).
SC group: in all cases a ureter with no alterations was observed although with slight periureteral fibrosis. AU group: some ureter specimens had a smaller caliber. Periureteral fibrosis was observed in all the cases. Vessel distribution was similar to that of the NU group. All the ureters conserved their lumen. 53.8% of the ureters showed spontaneous contractions and 100% contractions after mechanical stimulation. Cyst formation, necrosis, fistulas or stenosis of the lumen were not observed. RU group: microscopic findings of the ureter segment used as IAFG were compatible with those of a normal ureter. In all the cases a moderate degree of periureteral fibrosis was observed. In the majority of the cases a vascular framework of the fat immediately adjacent to the ureter was observed. In 13 of the 14 operated cases spontaneous contractions were observed. The ureteral segment used as IAFG showed no alterations in 10 cases and with alterations of various types in 4 cases. In 8 cases there was a greater or lesser degree of stenosis of the proximal suture.
The surgical findings and the macroscopic aspects of the four groups show the viability of the ureter free graft, IAFG as well as the NIAFG, in spite of the macroscopic changes.
建立两种大鼠实验模型，以研究输尿管在完全去血管化和去神经支配条件下的情况。
将输尿管作为完整的自体游离移植物（IAFG）进行自体移植，或作为非完整的自体游离移植物（NIAFG）弃置于腹膜后。将两种模型与正常组和手术对照组进行比较。62只大鼠随机分组：正常输尿管（NU）组（n = 20）；手术对照组，仅行输尿管松解术（SC）组（n = 15）；弃置输尿管作为NIAFG（AU）组（n = 13）；重新植入输尿管作为IAFG（RU）组（n = 14）。
SC组：所有病例均观察到输尿管无改变，尽管输尿管周围有轻微纤维化。AU组：一些输尿管标本管径较小。所有病例均观察到输尿管周围纤维化。血管分布与NU组相似。所有输尿管均保持管腔通畅。53.8%的输尿管显示自发收缩，机械刺激后100%收缩。未观察到囊肿形成、坏死、瘘管或管腔狭窄。RU组：用作IAFG的输尿管段的微观表现与正常输尿管相符。所有病例均观察到中等程度的输尿管周围纤维化。大多数病例观察到紧邻输尿管的脂肪有血管框架。14例手术病例中有13例观察到自发收缩。用作IAFG的输尿管段10例无改变，4例有各种类型的改变。8例近端缝合处有不同程度的狭窄。
四组的手术结果和宏观表现表明，尽管有宏观变化，但输尿管游离移植物（IAFG和NIAFG）仍具有活力。
