恰加斯心肌病的心脏移植
Heart transplantation for Chagas' cardiomyopathy.
作者信息
Blanche C, Aleksic I, Takkenberg J J, Czer L S, Fishbein M C, Trento A
机构信息
Department of Cardiothoracic Surgery, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA.
出版信息
Ann Thorac Surg. 1995 Nov;60(5):1406-8; discussion 1408-9. doi: 10.1016/0003-4975(95)00726-2.
We present 2 patients who underwent orthotopic heart transplantation for end-stage Chagas' cardiomyopathy. Despite immunosuppressive therapy, postoperative prophylaxis with nifurtimox appeared to prevent Trypanosoma cruzi reactivation. Neither patient has shown signs of Chagas' myocarditis, and both are clinically well 12 and 72 months after transplantation. The successful outcome of our patients suggests that heart transplantation is a reasonable therapeutic option in patients with end-stage Chagas' cardiomyopathy.
我们报告了2例因终末期恰加斯心肌病接受原位心脏移植的患者。尽管进行了免疫抑制治疗，但术后使用硝呋莫司预防似乎可防止克氏锥虫再激活。两名患者均未出现恰加斯心肌炎的迹象，且在移植后12个月和72个月时临床状况良好。我们患者的成功结果表明，心脏移植是终末期恰加斯心肌病患者合理的治疗选择。
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