Zagrebin V M
Arkh Patol. 1995 Jul-Aug;57(4):89-92.
Current views on focal defect in colorectal mucosa as a risk factor for development of tumours are presented. It is characterized by such phenotypical changes of the mucosa as cell proliferation activation, changes in ornithine decarboxylase activity and polyamine synthesis, changes in the expression of the blood group antigens and associated carbohydrate antigens as well as the development of small adenomas. All these changes may be biological markers of colonic precancer.
本文介绍了目前关于结直肠黏膜局灶性缺陷作为肿瘤发生危险因素的观点。其特征在于黏膜的表型变化，如细胞增殖激活、鸟氨酸脱羧酶活性和多胺合成的变化、血型抗原和相关碳水化合物抗原表达的变化以及小腺瘤的发生。所有这些变化可能是结肠癌前病变的生物学标志物。
