Gordon S
University of Oxford, Sir William Dunn School of Pathology, UK.
Bioessays. 1995 Nov;17(11):977-86. doi: 10.1002/bies.950171111.
The macrophage plays an important role in host development and physiology, and in pathogenesis of many infectious, immunologic and degenerative disease processes. It displays marked heterogeneity of phenotype in different tissues, reflecting local interactions with other cell types, and contributes to host homeostasis through a varied repertoire of plasma membrane and secretory molecules. Upon isolation from the body it continues to express special, as well as general, features of cellular organisation and function, which make it a delight to study in cell culture.
巨噬细胞在宿主发育和生理过程中以及在许多感染性、免疫性和退行性疾病进程的发病机制中发挥着重要作用。它在不同组织中表现出明显的表型异质性，反映了与其他细胞类型的局部相互作用，并通过多种质膜和分泌分子有助于宿主的内环境稳定。从体内分离后，它继续表达细胞组织和功能的特殊以及一般特征，这使得它在细胞培养中成为一种令人愉悦的研究对象。
