DiPietro L A
Department of Surgery, Loyola University Medical Center, Maywood, Illinois 60153, USA.
Shock. 1995 Oct;4(4):233-40.
The tissue macrophage has been shown to play a critical role in the wound healing process. Through the generation of bioactive substances, macrophages orchestrate the complex processes of cellular proliferation and functional tissue regeneration within wounds. Recent investigations have enumerated many of the specific proteins that are produced by wound macrophages at the site of injury. These include the following: 1) chemoattractants that recruit and activate additional macrophages at the site of injury, 2) growth factors that promote cellular proliferation and protein synthesis, 3) proteases and extra-cellular matrix molecules, and 4) factors that may restrain tissue growth once repair is completed. The development of therapeutic strategies to modulate wound repair continues to utilize key macrophage secretory products.
组织巨噬细胞已被证明在伤口愈合过程中起关键作用。通过产生生物活性物质，巨噬细胞协调伤口内细胞增殖和功能性组织再生的复杂过程。最近的研究列举了伤口巨噬细胞在损伤部位产生的许多特定蛋白质。这些包括：1）趋化因子，可在损伤部位募集和激活额外的巨噬细胞；2）促进细胞增殖和蛋白质合成的生长因子；3）蛋白酶和细胞外基质分子；4）一旦修复完成可能抑制组织生长的因子。调节伤口修复的治疗策略的发展继续利用关键的巨噬细胞分泌产物。
