Ransmayr G, Künig G, Neubauer M, Wagner M, Falk M
Department of Neurology, University of Innsbruck, Austria.
J Neural Transm Park Dis Dement Sect. 1995;9(2-3):177-88. doi: 10.1007/BF02259659.
One hundred and fifty patients suffering from Parkinson's disease were analysed for the expression of the motor symptoms during optimum response to levodopa therapy (subscale III of the Unified-Parkinson's Disease Rating Scale). Patients were grouped according to age (< or = 64, 65-74, > or = 75 years). Disease duration and daily levodopa dosage were similar in the three groups. Pooled residual scores for posture and gait impairment (PGI), tremor (T), rigidity (R) and distal motor impairment (DMI; hand and foot movements) increased with age (Kruskal-Wallis ANOVA). The parkinsonian scores were significantly higher than the scores of 150 age-matched normal controls (Mann-Whitney U test). The differences between the patients' scores and the scores of the age-matched controls increased with age. In spite of a significant increase in the daily levodopa dosage with disease duration (linear regression), PGI aggravated age-dependently, and DMI age-independently with symptom duration (Spearman rank correlation). In contrast, T and R did not increase with disease duration.
对150例帕金森病患者在左旋多巴治疗最佳反应期（统一帕金森病评定量表III分量表）的运动症状表达进行分析。患者按年龄分组（≤64岁、65 - 74岁、≥75岁）。三组患者的病程和每日左旋多巴剂量相似。姿势和步态障碍（PGI）、震颤（T）、强直（R）和远端运动障碍（DMI；手和足部运动）的合并残余评分随年龄增加（Kruskal - Wallis方差分析）。帕金森病评分显著高于150名年龄匹配的正常对照者（Mann - Whitney U检验）。患者评分与年龄匹配对照者评分之间的差异随年龄增加。尽管每日左旋多巴剂量随病程显著增加（线性回归），但PGI随年龄加重，DMI随症状持续时间加重且与年龄无关（Spearman等级相关）。相比之下，T和R不随病程增加。
