Lorenc-Koci E, Ossowska K, Wardas J, Wolfarth S
Department of Neuropsychopharmacology, Institute of Parmacology, Polish Academy of Sciences, Kraków, Poland.
J Neural Transm Park Dis Dement Sect. 1995;9(2-3):211-23. doi: 10.1007/BF02259662.
The aim of the study was to find out whether the reserpine-induced rigidity is similar to that seen in parkinsonism. Simultaneous measurements of the muscle resistance of the hind foot to passive bending and stretching in the ankle joint, as well as of the electromyographic (EMG) activity of the gastrocnemius and tibialis anterior muscles of rats were carried out. Reserpine was injected in a dose of 10 mg/kg alone or with alpha-methyl-p-tyrosine (250 mg/kg) 1, 4 and 27.5 h before the measurements. Reserpine increased the muscle resistance of the rat's hind leg to passive movements. That effect was the strongest at 1-2 h after the injections, and diminished markedly afterwards. The rigidity was accompanied with an increase in the resting, as well as in the stretch-induced short- and long-latency EMG activity in the gastrocnemius muscle. However, the intensity of the latter symptom did not change for a long period of time, which seems to correlate with the striatal dopamine depletion. The results suggest that the reserpine-increased EMG activity is a good model of parkinsonian rigidity.
该研究的目的是查明利血平诱导的僵硬是否与帕金森病中所见的僵硬相似。对大鼠后足在踝关节处被动弯曲和伸展时的肌肉阻力以及腓肠肌和胫前肌的肌电图（EMG）活动进行了同步测量。在测量前1、4和27.5小时，单独以10mg/kg的剂量注射利血平，或与α-甲基对酪氨酸（250mg/kg）一起注射。利血平增加了大鼠后腿对被动运动的肌肉阻力。该效应在注射后1-2小时最强，之后明显减弱。僵硬伴随着腓肠肌静息时以及拉伸诱导的短潜伏期和长潜伏期EMG活动增加。然而，后一种症状的强度在很长一段时间内没有变化，这似乎与纹状体多巴胺耗竭有关。结果表明，利血平增加的EMG活动是帕金森病僵硬的一个良好模型。
