Ossowska K, Lorenc-Koci E, Schulze G, Wolfarth S
Department of Neuropsychopharmacology, Polish Academy of Sciences, Kraków, Poland.
Neurosci Lett. 1996 Jan 19;203(2):73-6. doi: 10.1016/0304-3940(95)12264-8.
The electromyographic (EMG) stretch reflex in the gastrocnemius and tibialis anterior muscles was elicited by passive bending and stretching of the rat's hind foot in the ankle joint. The EMG stretch reflex was increased by pretreatment with reserpine (10 mg/kg ip) which is a model compound commonly used to induce parkinsonian rigidity in laboratory animals. Dizocilpine (MK-801) (0.32, 0.64 and 1.28 mg/kg sc) inhibited long-latency supraspinal components of the reserpine-increased EMG stretch reflex, whereas a short-latency spinal component was not diminished. The present results suggest that MK-801 exhibits an antiparkinsonian action against reserpine-induced rigidity.
通过被动弯曲和伸展大鼠踝关节处的后足来引发腓肠肌和胫骨前肌的肌电图（EMG）牵张反射。利血平（10mg/kg腹腔注射）预处理可增强EMG牵张反射，利血平是实验室动物中常用于诱发帕金森氏症僵硬的一种典型化合物。地卓西平（MK-801）（0.32、0.64和1.28mg/kg皮下注射）可抑制利血平增强的EMG牵张反射的长潜伏期脊髓上成分，而短潜伏期脊髓成分并未减弱。目前的结果表明，MK-801对利血平诱导的僵硬表现出抗帕金森病作用。
